Key result
Comparative sequence analysis of T4-like phages confirms that PeSL sequences mediate genomic diversity by serving as points of genetic exchange within hyperplastic regions.
Population
Two T4-like phages, PST (168 kb, 272 open reading frames [ORFs]) and nt-1 (248 kb, 405 ORFs)
Design
Preclinical
Authors
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PeSL recombination may shape phage adaptation; leaves open relevance to human pathogens or therapeutic vectors.
PeSL sequences play an important role in facilitating phage adaptation to new hosts and environments by mediating homologous recombination.
Comeau et al. (2014) studied T4-like phages (n=2). Comparative sequence analysis was evaluated on Genomic diversity and PeSL-mediated recombination. Comparative sequence analysis of T4-like phages confirms that PeSL sequences mediate genomic diversity by serving as points of genetic exchange within hyperplastic regions.
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