Synthesis of protected oligo (γ‐methyl‐ L ‐glutamates) and study of their conformation in solution and at the air–water interface

Oligopeptides having the general formula N‐carbobenzoxy(γ‐methyl‐L‐glutamyl)n‐dimethyl‐L‐glutamate (with n = 1, 3, 5, 7, 11) were prepared, using both solid‐phase synthesis and conventional peptide couplings in solution. The appearance of an ordered structure with increasing chain length was studied in organic solvents and at the air–water interface. The results obtained by thin‐layer chromatography were interpreted. All the studies have demonstrated a very similar behaviour of this type of oligopeptide in solution and in monolayers.