Answers are grounded in this paper and cite their sources.
Neuropathological evaluation demonstrates mineralized necrotic brain stem lesions in two Mobius syndrome patients, suggesting prenatal tissue destruction rather than primary developmental failure.
Möbius syndrome undoubtedly results from a variety of disorders affecting central or peripheral portions of appropriate cranial nerves or their target muscles. Pathological alterations observed in cranial nuclei are most often viewed as aplastic or dysplastic lesions. Two patients with Möbius syndrome with associated facial and skeletal malformations showed mineralized necrotic foci in multiple brain stem nuclei. Prenatal encephalomalacic lesions represent the pathological basis for some cases of congenital static Möbius syndrome.
No takes yet. Share an insight, caveat, or question.
Thakkar et al. (1977) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: