Key result
Higher preoperative BMI was an independent predictor of a lower likelihood of successful weight loss (OR 0.57) 24 months after Roux-en-Y gastric bypass surgery.
Why the study?
Roux-en-Y gastric bypass is standard for severe obesity, but some patients do not achieve expected weight loss success, leaving predictors unclear.
Cohort (n=63)
No
Odds Ratio: 0.57 (95% CI 0.32–0.76)
p-value: p=0.005
Lower preoperative BMI and greater initial weight loss at 12 months are key predictors of successful long-term weight loss following Roux-en-Y gastric bypass.
Higher preoperative BMI may flag higher risk of insufficient long-term loss after bypass; hypothesis-generating for refined selection pending prospective trials.
Background: Roux-en-Y gastric bypass (RYGB) is a standard treatment for severe obesity, but some patients do not achieve the expected success in weight loss. The aim of this study was to evaluate possible predictors of weight loss after RYGB. Methods: ) genes were investigated. Excess weight loss (EWL) >50% was considered to be successful weight loss (SWL). Logistic regression models were used to verify predictor variables. Results: (interquartile range, 46 to 58). At 12 and 24 months after surgery, EWL was 63% and 67%, and the failure rate was 19% and 16%, respectively. The individuals with insufficient weight loss (IWL) after 12 months had higher preoperative weight, BMI, and overweight. At 24 months, lowest frequency of individuals with SWL in the first year was found in the IWL group. No significant differences were found between the groups in dietary intake and PAL. In the logistic regression, high initial BMI was a predictor of the worst response in both periods, and high initial total weight loss was a predictor of a better response at 24 months. The polymorphism analysis did not show differences between groups in either gene. Conclusion: Lower preoperative BMI and greater weight loss at 12 months were predictors of SWL after RYGB.
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Alvarez‐Leite et al. (2024) conducted a cohort in Severe obesity (n=63). Preoperative body mass index (BMI) vs. Lower preoperative BMI was evaluated on Successful weight loss (excess weight loss > 50%) at 24 months (OR 0.57, 95% CI 0.32-0.76, p=0.005). Higher preoperative BMI was an independent predictor of a lower likelihood of successful weight loss (OR 0.57) 24 months after Roux-en-Y gastric bypass surgery.
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