Key result
Preconditioning of mesenchymal stem cells with SDF-1 enhanced cell survival, proliferation, and engraftment, reduced infarct size, and improved cardiac function in infarcted myocardium.
Why the study?
Does preconditioning mesenchymal stem cells with SDF-1 improve cell survival, engraftment, and cardiac function in a rat model of myocardial infarction?
Population
Cultured bone marrow-derived mesenchymal stem cells in vitro, and rats with left anterior descending…
Comparison
Mesenchymal stem cells preconditioned with… vs Non-preconditioned mesenchymal stem cells…
Design
Preclinical
Follow-up
4 weeks
Authors
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May improve MSC therapy for MI; leaves open translation from rat models to clinical use.
Does preconditioning mesenchymal stem cells with SDF-1 improve cell survival, engraftment, and cardiac function in a rat model of myocardial infarction?
Preconditioning mesenchymal stem cells with SDF-1 enhances their survival and engraftment, leading to improved myocardial function and reduced infarct size in a rat model of myocardial infarction.
Pasha et al. (2007) studied Infarcted myocardium. Preconditioning with stromal-derived factor 1 alpha (SDF-1) vs. Non-preconditioned MSCs (control group) was evaluated on Cell survival, proliferation, infarct size, fibrosis, and cardiac function. Preconditioning of mesenchymal stem cells with SDF-1 enhanced cell survival, proliferation, and engraftment, reduced infarct size, and improved cardiac function in infarcted myocardium.
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