Key result
The AST/ALT ratio was significantly higher in patients with slow coronary flow compared to controls (p<0.001) and positively correlated with TIMI frame counts in all coronary arteries.
Why the study?
To assess the correlation between the ratio of aspartate aminotransferase and alanine aminotransferase and slow coronary flow.
Is the AST/ALT ratio associated with the coronary slow-flow phenomenon?
Cross-Sectional (n=240)
Is the AST/ALT ratio associated with the coronary slow-flow phenomenon?
p-value: p=<0.001
The AST/ALT ratio is significantly elevated in patients with slow coronary flow and correlates positively with TIMI frame counts, suggesting it may serve as a predictive biomarker for this phenomenon.
AST/ALT ratio was associated with slow coronary flow; hypothesis-generating and requires prospective validation before any clinical role.
Aim: To assess the correlation between the ratio of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and slow coronary flow (SCF). Methods: A total of 119 patients with SCF and 121 age- and sex-matched patients with normal coronary flow were included in this retrospective cross-sectional study. Thrombolysis in myocardial infarction frame count of angiography images was marked by two interventionalists. In addition to AST and ALT levels, complete blood count; kidney, liver and thyroid function tests; age; sex; medication and medical history were recorded. Results: Significant spikes in AST/ALT ratio were discovered in the SCF group compared with the normal coronary flow group (p < 0.001). Thrombolysis in myocardial infarction frame count values were significantly higher in all coronaries for the SCF group compared with the normal coronary flow group (p < 0.001). Thrombolysis in myocardial infarction frame count values of the left anterior descending artery (r = 0.258; p < 0.001), left circumflex artery (r = 0.297; p < 0.001) and right coronary artery (r = 0.195; p = 0.002) were positively correlated with AST/ALT ratio. Conclusion: AST/ALT ratio is significantly correlated with SCF; therefore, this ratio may have predictive value.
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Akbuğa et al. (2022) conducted a cross-sectional in Slow coronary flow (n=240). Aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio vs. Normal coronary flow was evaluated on Presence of slow coronary flow and Thrombolysis in myocardial infarction frame count (p=<0.001). The AST/ALT ratio was significantly higher in patients with slow coronary flow compared to controls (p<0.001) and positively correlated with TIMI frame counts in all coronary arteries.
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