The First High-yielding Benzyne Cyclisation Using a Phenolic Nucleophile: A New Route to Xanthenes

All articles of this category Condensation of dianion 2 derived from aminobenzotriazole 1 with O -benzyl-salicylaldehydes 11 gives intermediate alcohols 12 in good yields. Double hydrogenolysis gives phenols 13 which, upon deprotection and benzyne generation using N -iodosuccinimide, undergo smooth cyclisation to give the iodo-xanthenes 14 in excellent overall yields. benzyne - intramolecular - nucleophilic - trapping - xanthene