Background: Colorectal cancer has high incidence and mortal rate in China. Chronic inflammatory intestine diseases are ascribed to precancerous lesion of colorectal cancer because of its close relationship with each other. TCM therapy has good effect in the prevention and treatment of inflammatory bowel diseases related colorectal cancer. Objective: To explore the preventive and therapeutic effects of Coptis chinensis and traditional Chinese medicine compound containing Coptis chinensis on inflammatory bowel disease and colorectal cancer. Methods: This paper reviews the sections in classical TCM books and recent report of clinical and experimental research on the formulars composed of Coptidis Rhizoma and the single drug in treating ulcerative colitis, intestinal polyps and colorectal cancer. By analyzing the data reported in the original literature, The mostly applied herbal formulas in the clinic including Gegen Qinlian Decoction, Dark Plum Pill and Banxia Xiexin Decoction were studied in detail. Results: Coptidis Rhizoma has the function of clearing away heat and drying dampness, purging fire and detoxification, benefiting intestine and stopping diarrhea. Several formulas composed of Coptidis Rhizoma are applied to treat inflammatory bowel diseases and colorectal cancer. Conclusion: Coptidis Rhizoma and its composition has the function of inhibiting intestinal inflammation, regulating intestinal flora, protecting intestinal barrier, and etc.
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Yan et al. (2021) studied this question.
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