Key result
Palmitylcarnitine and elevated external calcium ions similarly influenced sodium and calcium channel operation in avian ventricular muscle, likely via an effect on membrane surface charge.
Why the study?
Does L-palmitylcarnitine affect excitatory ionic currents similarly to elevated calcium ions in avian ventricular muscle?
Population
Avian ventricular muscle
Comparison
L-palmitylcarnitine (3 X 10 to 3 X 10M) and… vs Baseline conditions or normal external calcium ion
Design
Preclinical
Authors
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Suggests shared surface-charge effects on avian ion channels; leaves open relevance to mammalian electrophysiology or arrhythmias.
Does L-palmitylcarnitine affect excitatory ionic currents similarly to elevated calcium ions in avian ventricular muscle?
L-palmitylcarnitine affects sodium and calcium channel operation in avian ventricular muscle similarly to elevated external calcium, likely by influencing membrane surface charge.
Inoue et al. (1983) studied this question. Palmitylcarnitine and elevated external calcium ion vs. Normal external calcium (1.8 mM) / baseline was evaluated on Excitatory ionic currents (fast sodium and slow calcium channels). Palmitylcarnitine and elevated external calcium ions similarly influenced sodium and calcium channel operation in avian ventricular muscle, likely via an effect on membrane surface charge.
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