Key result
Elevated levels of pro-adrenomedullin and pro-atrial natriuretic peptide immediately after cardiopulmonary bypass significantly predicted the need for mechanical ventilation with AUCs of 0.721 and 0.746, respectively.
Why the study?
To evaluate procalcitonin, pro-adrenomedullin, and pro-atrial natriuretic peptide as predictors of mechanical ventilation and postoperative complications in critically ill pediatric patients after cardiopulmonary bypass.
Do serum levels of procalcitonin, pro-adrenomedullin, and pro-atrial natriuretic peptide predict the need for mechanical ventilation and postoperative complications in pediatric patients after cardiopulmonary bypass?
Observational (n=111)
Clinicians were blinded to biomarker results
No
Do serum levels of procalcitonin, pro-adrenomedullin, and pro-atrial natriuretic peptide predict the need for mechanical ventilation and postoperative complications in pediatric patients after cardiopulmonary bypass?
Effect estimate: AUC 0.746 (95% CI 0.589-0.881)
p-value: p=0.002
Pro-adrenomedullin and pro-atrial natriuretic peptide measured immediately after cardiopulmonary bypass in pediatric patients can help predict the need for mechanical ventilation, while procalcitonin is useful for predicting bacterial infection.
No takes yet. Share an insight, caveat, or question.
Bobillo‐Pérez et al. (2019) conducted an observational in Critically ill pediatric patients after cardiopulmonary bypass (n=111). Pro-adrenomedullin and pro-atrial natriuretic peptide levels vs. Lower biomarker levels was evaluated on Need for mechanical ventilation (AUC 0.746, 95% CI 0.589-0.881, p=0.002). Elevated levels of pro-adrenomedullin and pro-atrial natriuretic peptide immediately after cardiopulmonary bypass significantly predicted the need for mechanical ventilation with AUCs of 0.721 and 0.746, respectively.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: