Key result
Human adenovirus type 36 (HAdV-36) infection was significantly associated with obesity (OR 1.84; 95% CI 1.39-2.43), especially in children younger than 18 years (OR 2.44; 95% CI 1.85-3.22).
Why the study?
Human adenovirus type 36 (HAdV-36) infections have been suggested to possibly be associated with obesity.
Is human adenovirus type 36 (HAdV-36) infection associated with obesity?
Meta-Analysis
Is human adenovirus type 36 (HAdV-36) infection associated with obesity?
Human adenovirus type 36 infection is significantly associated with obesity, particularly in adolescents, suggesting a potential infectious contributor to obesity risk.
HAdV-36–obesity link, stronger in children, merits causal inquiry; leaves open whether infection influences prevention or management strategies.
As a health problem, obesity has several risk factors; it has been suggested that human adenovirus type 36 (HAdV-36) infections may possibly be associated with obesity. This updated meta-analysis was designed and conducted with an emphasis on articles published from 2015 to 2020. The PubMed, Web of Science, and Scopus databases were searched up to 1 December 2020. Overall, pooled prevalence and odds ratio of antibodies against HAdV-36 in people with obesity and controls was assessed among different ages. Case-control and cohort studies were included in the analysis. The overall prevalence of HAdV-36 infection in obese population was 31% (CI: 0.24%-0.38%) which was 32% in cases and 27% in controls, respectively; a significant association was found between the cases and the controls (OR, 1.84; 95% CI, 1.39-2.43), especially in children younger than 18 years of age (OR, 2.44; 95% CI, 1.85-3.22). A significant association between adenovirus infection and obesity was found, especially in adolescents.
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Marjani et al. (2021) conducted a meta-analysis in Obesity. Human adenovirus type 36 (HAdV-36) infection vs. Controls without obesity was evaluated on Obesity (OR 1.84, 95% CI 1.39-2.43). Human adenovirus type 36 (HAdV-36) infection was significantly associated with obesity (OR 1.84; 95% CI 1.39-2.43), especially in children younger than 18 years (OR 2.44; 95% CI 1.85-3.22).
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