Key result
Garcinia cambogia extract ameliorated high-fat diet-induced obesity in mice by lowering body weight gain, visceral fat, and lipid concentrations, likely by modulating adipogenesis genes.
Why the study?
Does Garcinia cambogia extract reduce obesity and modulate adipogenesis genes in C57BL/6J mice fed a high-fat diet?
Does Garcinia cambogia extract reduce obesity and modulate adipogenesis genes in C57BL/6J mice fed a high-fat diet?
Garcinia cambogia extract ameliorates high-fat diet-induced obesity in mice, likely by modulating genes associated with adipogenesis.
Animal data only; leaves open translation of Garcinia cambogia effects on obesity to humans.
The aim of present study is to evaluate the effects of Garcinia cambogia on the mRNA levels of the various genes involved in adipogenesis, as well as on body weight gain, visceral fat accumulation, and other biochemical markers of obesity in obesity-prone C57BL/6J mice. Consumption of the Garcinia cambogia extract effectively lowered the body weight gain, visceral fat accumulation, blood and hepatic lipid concentrations, and plasma insulin and leptin levels in a high-fat diet (HFD)-induced obesity mouse model. The Garcinia cambogia extract reversed the HFD-induced changes in the expression pattern of such epididymal adipose tissue genes as adipocyte protein aP2 (aP2), sterol regulatory element-binding factor 1c (SREBP1c), peroxisome proliferator-activated receptor gamma2 (PPARgamma2), and CCAT/enhancer-binding protein alpha (C/EBPalpha). These findings suggest that the Garcinia cambogia extract ameliorated HFD-induced obesity, probably by modulating multiple genes associated with adipogenesis, such as aP2, SREBP1c, PPARgamma2, and C/EBPalpha in the visceral fat tissue of mice.
No takes yet. Share an insight, caveat, or question.
Kim et al. (2008) studied High-fat diet (HFD)-induced obesity. Garcinia cambogia extract vs. High-fat diet alone was evaluated on mRNA levels of adipogenesis genes, body weight gain, visceral fat accumulation, and biochemical markers. Garcinia cambogia extract ameliorated high-fat diet-induced obesity in mice by lowering body weight gain, visceral fat, and lipid concentrations, likely by modulating adipogenesis genes.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: