Key result
Children with HFMD demonstrated a reduction in butyrate-producing bacteria such as Ruminococcus (0.73 vs 7.78, p=0.026) and an up-regulation of Escherichia (5.26 vs 1.59, p<0.01).
Why the study?
Does the gut microbiota composition differ between children with hand, foot and mouth disease and healthy controls?
Case-Control (n=30)
No
Does the gut microbiota composition differ between children with hand, foot and mouth disease and healthy controls?
Absolute Event Rate: 0.73% vs 7.78%
p-value: p=0.026
Children with hand, foot and mouth disease exhibit gut microbiota dysbiosis characterized by decreased butyrate-producing bacteria and increased inflammation-inducing bacteria.
HFMD was associated with gut dysbiosis; hypothesis-generating for microbiota-targeted interventions in enteroviral disease.
AIM: This study explored the gut microbiota of children with hand, foot and mouth disease (HFMD). METHODS: We enrolled 15 cases with HFMD admitted to the West China Second Hospital, Sichuan University, China, from July to September 2016 at a median age of three years. The controls were 15 healthy children of a similar age who underwent routine health examinations at the hospital during the same period. Gut microbiota was analysed using high throughput 16S ribosomal deoxyribonucleic acid sequencing. RESULTS: The gut microbiota in the HFMD patients was distinct from the controls. Compared with the controls, the composition of gut microbiota in the HFMD cases represented a reduction of two butyrate-producing bacteria, Ruminococcus (0.73 ± 1.28 versus 7.78 ± 20.01, p = 0.026) and Roseburia (0.67 ± 1.69 versus 1.61 ± 3.27, p = 0.024) and an up-regulation of Escherichia (5.26 ± 10.50 versus 1.59 ± 5.90,p < 0.01) and Enterococcus (4.12 ± 12.49 versus 0.12 ± 0.41, p = 0.015). CONCLUSION: The dysbiosis of gut microbiota of the HFMD cases included a reduction of butyrate-producing bacteria and an up-regulation of inflammation-inducing bacteria. These may have impaired the intestinal biological mucosal barrier and host immune functions, promoting the invasion of the enterovirus.
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Li et al. (2018) conducted a case-control in Hand, foot and mouth disease (HFMD) (n=30). Hand, foot and mouth disease (HFMD) vs. Healthy children was evaluated on Ruminococcus abundance (p=0.026). Children with HFMD demonstrated a reduction in butyrate-producing bacteria such as Ruminococcus (0.73 vs 7.78, p=0.026) and an up-regulation of Escherichia (5.26 vs 1.59, p<0.01).
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