Key result
Treatment with digoxin prevented the initiation of exercise-induced adenosine-sensitive ventricular tachycardia, leaving the patient symptom-free for 10 months.
Why the study?
Does digoxin prevent arrhythmia initiation and symptoms in a patient with adenosine-sensitive ventricular tachycardia?
Case Report (n=1)
Does digoxin prevent arrhythmia initiation and symptoms in a patient with adenosine-sensitive ventricular tachycardia?
Digoxin successfully suppressed exercise-induced, adenosine-sensitive ventricular tachycardia in a single patient, suggesting a potential therapeutic role mediated by its autonomic effects.
Should not yet change practice in adenosine-sensitive VT; leaves open a potential role for digoxin warranting prospective evaluation.
Digitalis and Ventricular Tachycardia. Digoxin was used to treat a patient with an adenosine‐sensitive ventricular arrhythmia. The patient had an exercise‐induced ventricular tachycardia that was evaluated electrophysiologically and displayed characteristics of a triggered arrhythmia. The tachycardia was terminated reproducibly with 12 mg of intravenous adenosine. After treatment with digoxin (serum level = 1.7 ng/mL), the arrhythmia could no longer be initiated with programmed electrical stimulation or exercise treadmill testing. The patient has since remained symptom free for 10 months. The autonomic effects of digitalis are proposed to mediate drug efficacy in this form of ventricular tachycardia.
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Cook et al. (1991) conducted a case report in Adenosine-sensitive ventricular tachycardia (n=1). Digoxin was evaluated on Arrhythmia initiation with programmed electrical stimulation or exercise treadmill testing. Treatment with digoxin prevented the initiation of exercise-induced adenosine-sensitive ventricular tachycardia, leaving the patient symptom-free for 10 months.
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