Key result
The modeled on-chip capacitive biosensor demonstrated distinct capacitance bands in the order of 10^-14 F corresponding to different stages of hypertension based on simulated cardiac cycles.
Why the study?
Persistent high blood pressure leads to hypertension, prompting the design of an implantable lab-on-chip platform for continuous blood pressure monitoring to prevent chronic hypertensive disorders.
The simulated implantable electrostatic capacitive biosensor successfully differentiated stages of hypertension based on capacitance variations, demonstrating potential for continuous in vivo blood pressure monitoring.
High Blood Pressure (HBP) over a long period of time leads to a medical condition known as Hypertension (HTN or HT), in which the arterial blood pressure is persistently inflated. In this research, a blood pressure biosensor has been implemented that monitors the different stages of hypertension by measuring the varying blood pressure values. Further, a system design has been proposed for the theranostics (combination of diagnosis and therapy) of hypertension. The proposed sensor takes blood pressure as the input, and gives the corresponding electrical signal variations at the output, so as to detect the exact stage of hypertension. The working principle of this BP sensor is based on the electrostatic transduction mechanism. The proposed system aims to design a low-cost, easily available, implantable lab-on-chip (LoC) platform for the continuous measurement of blood pressure by keeping track of the patient history, so as to prevent chronic hypertensive disorders. Further, such an implantable LoC theranostic platform is among the best possible solutions for the e-healthcare systems, owing to its potential in a wireless body area network (WBAN) using Internet of Things (IoT) and other similar technologies.
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Gupta et al. (2021) studied Hypertension. On-chip capacitive biosensor model was evaluated on Capacitance and displacement corresponding to different blood pressure values. The modeled on-chip capacitive biosensor demonstrated distinct capacitance bands in the order of 10^-14 F corresponding to different stages of hypertension based on simulated cardiac cycles.
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