Key result
Higher FHL2 mRNA expression in lung cancer patients was associated with poorer overall survival and relapse-free survival (P<0.001) and demonstrated moderate diagnostic ability (AUC = 0.857).
Why the study?
Lung cancer causes high mortality globally, and whether high expression of the oncogenic gene FHL2 is associated with worse survival outcomes required demonstration.
Does high FHL2 mRNA expression predict worse overall survival and relapse-free survival in lung cancer patients?
Population
1018 lung cancer patients from TCGA and lung cancer cells
Comparison
High FHL2 expression vs lower expression levels
Design
Retrospective database and in vitro laboratory study
Authors
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High FHL2 expression signals worse lung cancer survival; leaves open its utility as a validated prognostic biomarker pending prospective confirmation.
Observational (n=1,018)
Does high FHL2 mRNA expression predict worse overall survival and relapse-free survival in lung cancer patients?
p-value: p=<0.001
High FHL2 mRNA expression is an independent predictor of poor prognosis in lung cancer patients and promotes cancer cell proliferation and invasion.
Jiao et al. (2022) conducted an observational in Lung cancer (n=1,018). High FHL2 mRNA expression vs. Low FHL2 mRNA expression was evaluated on Overall survival (OS) and relapse-free survival (RFS) (p=<0.001). Higher FHL2 mRNA expression in lung cancer patients was associated with poorer overall survival and relapse-free survival (P<0.001) and demonstrated moderate diagnostic ability (AUC = 0.857).
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