Key result
This review highlights that the mechanisms influencing blood pressure differences between genders, particularly in pre- and postmenopausal women, involve complex and incompletely understood factors.
This review highlights the complex mechanisms and management considerations for hypertension in women across pre- and post-menopausal phases, including pregnancy and hormonal therapy.
Caution against oversimplifying gender BP differences; leaves open targeted mechanistic research in pre- and postmenopausal women.
Post-menopausal women are reported as developing higher blood pressures than men of similar age, a feature that, in some way, explains why women develop similar cardiovascular risk to men. The management of hypertension in women is governed by two broad phases in their life: being either pre- or post-menopausal. In addition there are serious considerations regarding the choice of medication in women who are or might become pregnant, and in women using any form of hormonal manipulation or augmentation for contraceptive or replacement (HRT) therapy. This review offers an overview of the hypertensive status of women in these various phases of life. The influence of comorbidities, some of which are more applicable to women and their mechanisms, are reviewed. However, many of the mechanisms influencing blood pressure differences between the genders involve complex interrelationships, and in some instances remain incompletely understood.
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Simon W Dubrey (2013) conducted a review in Hypertension. Hypertension management and hormonal therapies was evaluated. This review highlights that the mechanisms influencing blood pressure differences between genders, particularly in pre- and postmenopausal women, involve complex and incompletely understood factors.
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