Central and peripheral effects of propranolol and sotalol in normal human subjects

No unequivocal central effects were found with either +/--propranolol (120 mg) or +/--sotalol (240 mg) in acute dosage in normal subjects. Subjective feelings of drowsiness and muzziness were found with sotalol and both sotalol and propranolol caused subjects to feel more troubled. These changes were not accompanied by physiological or behavioural evidence of sedation. Adequate beta-adrenoceptor blockade was achieved as measured by a significant fall in pulse-rate on both active drugs but no other significant peripheral physiological changes occurred.