Key result
Low-expression NPY genotypes were significantly overrepresented in subjects with major depressive disorder (P=0.004) and associated with increased neural responsivity to negative stimuli.
Why the study?
Does low-expression NPY genotype increase neural responsivity to negative stimuli and risk for major depressive disorder?
Population
181 individuals, including 44 with major depressive disorder (MDD) and 137 healthy controls.
Comparison
Low-expression neuropeptide Y (NPY) genotypes vs Intermediate or high-expression NPY genotypes
Design
Case-control
Authors
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May link NPY variation to depression risk; hypothesis-generating and should not yet change practice.
Case-Control (n=181)
No
Does low-expression NPY genotype increase neural responsivity to negative stimuli and risk for major depressive disorder?
p-value: p=0.004
Low-expression NPY genotypes are associated with increased neural responsivity to negative stimuli and a higher risk of major depressive disorder.
Mickey et al. (2011) conducted a case-control in Major depressive disorder (n=181). Low-expression NPY genotypes vs. Intermediate or high-expression NPY genotypes was evaluated on Genotype distribution between control subjects and subjects with major depressive disorder (p=0.004). Low-expression NPY genotypes were significantly overrepresented in subjects with major depressive disorder (P=0.004) and associated with increased neural responsivity to negative stimuli.
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