In search of the ‘bio‐active conformation’—Is it induced by the target cell membrane?

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Transferred nuclear Overhauser effect analyses of membrane-bound enkephalin analogs by proton nuclear magnetic resonance: correlation between activities and membrane-bound conformations1990 · 96 citations
2. 2Peptide–membrane interactions and a new principle in quantitative structure–activity relationships1991 · 101 citations
3. 3Emerging approaches in the molecular design of receptor-selective peptide ligands: conformational, topographical and dynamic considerations1990 · 520 citations
4. 4Activity and Distribution of Binding Sites in Brain of a Nonpeptide Substance P (NK ₁ ) Receptor Antagonist1991 · 217 citations
5. 5Cation dependence of opioid receptor binding supports theory on membrane-mediated receptor selectivity1988 · 23 citations