Key result
Circulating osteogenic precursor cells were identified in areas of calcification in human calcifying aortic valves, providing evidence for their role in the development of osteogenesis.
Population
Human calcifying aortic valves
Design
Editorial
Authors
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Hypothesis-generating for circulating precursors in valvular calcification; leaves open whether targeting them modifies disease progression.
This editorial highlights the first evidence that circulating osteogenic precursor cells are present in human calcifying aortic valves and play a role in the cellular mechanisms of osteogenesis.
Nalini M. Rajamannan (2011) conducted an editorial in Calcific aortic valve disease. Circulating osteogenic precursor cells (COP) vs. Unaffected tissues was evaluated on Presence of COP cells in areas of calcification. Circulating osteogenic precursor cells were identified in areas of calcification in human calcifying aortic valves, providing evidence for their role in the development of osteogenesis.
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