Key result
Among 1,050 children with acute gastroenteritis, norovirus was detected in 14.2%, with the novel GII.17 variant emerging as the second most predominant genotype (10.7% of positive cases).
Observational (n=1,050)
No
The novel norovirus GII.17 strain emerged as a significant and increasingly prevalent cause of acute gastroenteritis among children in South Korea between 2013 and 2015, exhibiting rapid genetic evolution.
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Of 1,050 fecal specimens collected from January 2013 to August 2015 from children with acute gastroenteritis, 149 (14.2%) were found to be positive for norovirus. Norovirus GII was the most predominant genogroup (98.65%; 147 of 149). The genotypes detected in this study were GI (2; 1.3%), GII.Pe-GII.4 (109; 73.1%), GII.P17-GII.17 (16; 10.7%), GII.P12-GII.3 (8; 5.4%), GII.P12-GII.12 (8; 5.4%), GII.P4-GII.4 (5; 3.4%), and the recombinant GII.Pe-GII.17 (1; 0.7%). Of these, the novel GII.17 strain was the second most predominant, and the number of affected children appeared to continuously increase over time (2013 [2; 4.4%], 2014 [4; 9.3%], and 2015 [10; 16.4%]). Phylogenetic analysis of the full genome and ORF1, ORF2, and ORF3 nucleotide sequences showed that GII.17 was grouped in cluster III with other strains isolated from 2013 to 2015 and had a different evolutionary history from strains collected in 1978 to 2002 and 2005 to 2009 formed clusters I and II. However, the phylogenetic trees also showed that cluster III was divided into subclusters IIIa (CAU-55 and CAU-85) and IIIb (Kawasaki 2014) (CAU-193, CAU-265, CAU-267, CAU-283, and CAU-289). Comparative analysis of the VP1 capsid protein using 15 complete amino acid sequences from noroviruses isolated from 1978 to 2015 showed 99 amino acid changes. These results could be helpful for epidemiological studies to understand circulating norovirus genotypes in population.
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Emerging GII.17 norovirus supports enhanced pediatric surveillance in South Korea; leaves open implications for diagnostics and vaccines.
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Dang et al. (2016) conducted an observational in Acute gastroenteritis (n=1,050). Norovirus GII.17 variant vs. Other norovirus genotypes (e.g., GII.4) was evaluated on Prevalence of Norovirus GII.17 among norovirus-positive acute gastroenteritis cases. Among 1,050 children with acute gastroenteritis, norovirus was detected in 14.2%, with the novel GII.17 variant emerging as the second most predominant genotype (10.7% of positive cases).
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