Key result
Whole genome sequencing of three norovirus GII.17 strains from South Korean children with acute gastroenteritis revealed numerous amino acid changes in the protruding P2 domain of VP1 compared to global isolates.
Why the study?
Norovirus vaccines have not been developed, making prediction and prevention important, especially following the emergence of the novel GII.17 variant with increased incidence.
Cross-Sectional (n=204)
Whole genome sequencing of norovirus GII.17 strains from South Korean children revealed numerous amino acid changes in the P2 domain of VP1, providing genomic data that may aid in epidemic prevention and vaccine development.
Ongoing surveillance for norovirus variants is warranted; leaves open antigenic and vaccine implications pending functional studies.
Norovirus, a major cause of gastroenteritis in people of all ages worldwide, was first reported in South Korea in 1999. The most common causal agents of pediatric acute gastroenteritis are norovirus and rotavirus. While vaccination has reduced the pediatric rotavirus infection rate, norovirus vaccines have not been developed. Therefore, prediction and prevention of norovirus are very important. Norovirus is divided into genogroups GI-GVII, with GII.4 being the most prevalent. However, in 2012-2013, GII.17 showed a higher incidence than GII.4 and a novel variant, GII.P17-GII.17, appeared. In this study, 204 stool samples collected in 2013-2014 were screened by reverse transcriptase-polymerase chain reaction; 11 GI (5.39%) and 45 GII (22.06%) noroviruses were identified. GI.4, GI.5, GII.4, GII.6 and GII.17 were detected. The whole genomes of the three norovirus GII.17 were sequenced. The whole genome of GII.17 consists of three open reading frames of 5109, 1623 and 780 bp. Compared with 20 GII.17 strains isolated in other countries, we observed numerous changes in the protruding P2 domain of VP1 in the Korean GII.17 viruses. Our study provided genome information that might aid in epidemic prevention, epidemiology studies and vaccine development.
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Kim et al. (2019) conducted a cross-sectional in Acute gastroenteritis (n=204). Norovirus infection was evaluated on Detection and genomic characterization of norovirus GII.17. Whole genome sequencing of three norovirus GII.17 strains from South Korean children with acute gastroenteritis revealed numerous amino acid changes in the protruding P2 domain of VP1 compared to global isolates.
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