Key result
Plasma PEP and DPP IV activities exhibited significant seasonal variation, with PEP peaking in the fall and DPP IV peaking in the summer.
Observational (n=26)
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Plasma PEP and DPP IV activities exhibit significant seasonal variations and biological variability that should be considered when interpreting these biomarkers.
We investigated the components of biological variation in plasma prolyl endopeptidase (PEP; EC 3.4.21.26) and dipeptidyl-peptidase IV (DPP IV; EC 3.4..14.5) activity in healthy individuals. We took monthly blood samples from 26 healthy volunteers for determination of plasma PEP and DPP IV activity during one calendar year. The estimated CVs for PEP activity were: total (CVt) = 25.0%, interindividual (CVg) = 13.9%, and intraindividual (CVi) = 16.8%. There was a statistically significant (P < 0.0001) seasonal pattern in plasma PEP activity, with significantly higher values in the fall than in the other seasons. The peak-trough difference in the yearly variation in PEP activity, expressed as a percentage of the mean, was as high as 56.8%. The estimated CVs for DPP IV activity were: CVt = 17.1%, CVg = 14.5%, and CVi = 8.2%. DPP IV activity was significantly (P < 0.0001) higher in summer than in the other seasons but the amplitude of the yearly variation was small.
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Maes et al. (1994) conducted an observational in Healthy (n=26). Seasonal variation vs. Other seasons was evaluated on Biological variation in plasma PEP and DPP IV activity (p=<0.0001). Plasma PEP and DPP IV activities exhibited significant seasonal variation, with PEP peaking in the fall and DPP IV peaking in the summer.
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