Antidepressant-induced orgasm disorder

Most of the antidepressants approved for use in the United States, with the possible exceptions of bupropion and nefazodone, have been associated with drug-induced anorgasmia. Common strategies to overcome this drug side effect include waiting for tolerance to develop, dose reduction, change of dosing regimen, substitution of an alternative antidepressant, and coadministration of another drug. Current evidence suggests that antidepressant-induced anorgasmia may be mediated by 5HT2 antagonism of adrenergic mechanisms that underlie normal orgasm.