Key result
Lymphocyte ADIPORs mRNA expression and serum adiponectin were significantly lower in obese patients than in anorexic subjects (ADIPOR1, p < 0.005; ADIPOR2, p < 0.05).
Cross-Sectional (n=80)
p-value: p=<0.005
Lymphocyte ADIPOR1 and ADIPOR2 expression is markedly reduced in obese subjects compared to anorexic subjects, and correlates with serum adiponectin levels rather than directly with BMI or insulin resistance.
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ADIPOR downregulation in obesity should not yet alter management; leaves open mechanistic and therapeutic implications for adiponectin signaling.
Alberti et al. (2006) conducted a cross-sectional in Obesity and anorexia nervosa (n=80). Obesity vs. Anorexia nervosa was evaluated on Lymphocyte ADIPOR1 and ADIPOR2 mRNA expression (p=<0.005). Lymphocyte ADIPORs mRNA expression and serum adiponectin were significantly lower in obese patients than in anorexic subjects (ADIPOR1, p < 0.005; ADIPOR2, p < 0.05).
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