Key result
Lipid-lowering interventions may improve cardiovascular risk through non-lipid mechanisms, including beneficial effects on the arterial wall, endothelial function, blood rheology, and thrombogenesis.
Why the study?
Do lipid-lowering interventions influence rheological and haemostatic parameters?
Do lipid-lowering interventions influence rheological and haemostatic parameters?
Answers are grounded in this paper and cite their sources.
Lipid-lowering therapies may confer cardiovascular benefits through non-lipid mechanisms, including improvements in endothelial function, blood rheology, and thrombogenesis.
There is growing evidence that the components of the haemostatic system play a significant role in the development and progression of atherosclerosis and its complications. Lipid-lowering interventions have been associated with a significant reduction of morbidity and mortality. However, the improvement in cardiovascular risk seen in several clinical trials is incompletely explained by cholesterol reduction. Therefore, the benefit from lipid lowering drugs may involve non-lipid mechanisms. These include beneficial effects on the arterial wall, improved endothelial function and a favourable influence on blood rheology and thrombogenesis. In this review, we consider the influence of lipid-lowering interventions on rheological and haemostatic parameters as well as the potential clinical relevance of these effects.
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Milionis et al. (2003) conducted a review in Atherosclerosis and cardiovascular risk. Lipid-lowering interventions was evaluated on Rheological and haemostatic parameters. Lipid-lowering interventions may improve cardiovascular risk through non-lipid mechanisms, including beneficial effects on the arterial wall, endothelial function, blood rheology, and thrombogenesis.
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