What question did this study set out to answer?

To characterize the organ distribution, co-localization, and molecular weights of aminopeptidase A and dipeptidyl peptidase IV in normal mouse tissues.

May 1, 1996Journal of Histochemistry & CytochemistryOpen Access

Organ distribution of aminopeptidase A and dipeptidyl peptidase IV in normal mice.

View Full Paper

Ask AI

Bookmark

Authors

SMS. MentzelRadboud University Nijmegen HDHenry DijkmanHAN University of Applied Sciences JSJ P van SonChung-Ang University

Discussion

Member takes

Implication

Histological analysis demonstrates widespread distribution and partial co-localization of aminopeptidase A and dipeptidyl peptidase IV across normal mouse organs, suggesting broad biological roles.

Key Points

To characterize the organ distribution, co-localization, and molecular weights of aminopeptidase A and dipeptidyl peptidase IV in normal mouse tissues.
Evaluated the presence and co-distribution of both enzymes across mouse tissues using immunohistology with two rat monoclonal antibodies validated by immunodepletion.
Isolated hydrolases from mouse glomeruli, renal brush borders, and thymus using solid-phase immunoprecipitation and analyzed their molecular weights via SDS-PAGE.
Both enzymes exhibited differing molecular weights across the renal corpuscle, renal brush borders, and thymic cells.
Both hydrolases displayed extensive organ distribution with partial co-localization in the kidney, liver, small intestine, thymus, brain, spleen, and lymph nodes on identical or distinct cells.

Cite This Study

Mentzel et al. (1996) studied this question.

synapsesocial.com/papers/6a9a2839352e687f024d451b https://doi.org/10.1177/44.5.8627002

View Full Paper

Ask AI

Bookmark

Implication

Histological analysis demonstrates widespread distribution and partial co-localization of aminopeptidase A and dipeptidyl peptidase IV across normal mouse organs, suggesting broad biological roles.

Organ distribution of aminopeptidase A and dipeptidyl peptidase IV in normal mice.

Discussion

Member takes

Implication

Key Points

Cite This Study

Organ distribution of aminopeptidase A and dipeptidyl peptidase IV in normal mice.

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider