Key result
Sustained increased nitrosative stress in the headache-free period is associated with a 3.6-fold higher risk for migraine (OR 3.6).
Why the study?
Is increased nitric oxide stress in the headache-free period associated with migraine?
Observational (n=130)
Is increased nitric oxide stress in the headache-free period associated with migraine?
Odds Ratio: 3.6
Migraine patients experience sustained increased nitrosative stress during headache-free periods, which is associated with a 3.6-fold higher risk for migraine.
May support nitrosative stress as migraine biomarker; hypothesis-generating and requires prospective validation before any clinical use.
Nitric oxide (NO) has been implicated in migraine attacks, but the role of NO in migraine remains unclear. We here hypothesize that increased NO in the headache-free period is associated with migraine. One hundred and thirty probands participated in this study. Various parameters of the NO pathway, such as nitrate, nitrite, arginine, citrulline, nitrosylated proteins, asymmetric dimethylarginine, symmetrical dimethylarginine, expression of endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase and two polymorphisms of eNOS were investigated. We found significant increased nitrate and decreased nitrite levels in migraineurs in the headache-free period. Nitrate and nitrite levels showed a significant inverse correlation. Logistic regression revealed an odds ratio of 3.6 for migraine. Other parameters of the NO pathway were neither altered in migraineurs nor correlated with nitrate. We show here that migraine patients suffer under sustained increased nitrosative stress in the headache-free period, which is associated with a 3.6-fold higher risk for migraine.
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Gruber et al. (2009) conducted an observational in Migraine (n=130). Increased nitrosative stress was evaluated on Migraine (OR 3.6). Sustained increased nitrosative stress in the headache-free period is associated with a 3.6-fold higher risk for migraine (OR 3.6).
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