Key result
Structural and biochemical evidence suggests that catalysis and translocation are not tightly coupled in viral RNA-dependent RNA polymerases, unlike in A-family polymerases.
This review highlights the structural mechanisms of catalysis-translocation uncoupling in viral RNA-dependent RNA polymerases, providing insights into viral replication machinery.
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Uncoupling of catalysis and translocation in viral RdRPs may inform antiviral strategies; leaves open motif B loop as a therapeutic target pending validation.
Shu et al. (2017) conducted a review in Viral RNA-dependent RNA polymerases. Structural and biochemical evidence suggests that catalysis and translocation are not tightly coupled in viral RNA-dependent RNA polymerases, unlike in A-family polymerases.
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