Key result
17β-Estradiol repletion in ovariectomized rats with pulmonary hypertension markedly improved right ventricular function and hemodynamics after an acute exercise challenge.
Why the study?
Does 17β-Estradiol improve right ventricular adaptation to acute exercise in a rat model of severe pulmonary hypertension?
Does 17β-Estradiol improve right ventricular adaptation to acute exercise in a rat model of severe pulmonary hypertension?
17β-Estradiol exerts protective effects on right ventricular function and adaptation to acute exercise in a rat model of severe pulmonary hypertension.
No takes yet. Share an insight, caveat, or question.
E2 repletion may protect RV function in PH rat models; leaves open clinical translation.
Lahm et al. (2016) studied sugen/hypoxia (SuHx)-induced pulmonary hypertension. 17β-Estradiol (E2) vs. Ovariectomized (OVX) SuHx females without E2 repletion, intact females, and males was evaluated on Right ventricular function (echocardiographic, hemodynamic, structural, and biochemical markers). 17β-Estradiol repletion in ovariectomized rats with pulmonary hypertension markedly improved right ventricular function and hemodynamics after an acute exercise challenge.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: