Key result
Elevated C-reactive protein levels on the 5th postoperative day (12.5 mg/dL vs 5.7 mg/dL, p<0.05) significantly predicted the development of septic complications in patients undergoing colorectal cancer surgery.
Why the study?
Does serum CRP in the early postoperative period predict septic postoperative complications in colorectal cancer patients?
Cohort (n=278)
No
Does serum CRP in the early postoperative period predict septic postoperative complications in colorectal cancer patients?
Absolute Event Rate: 12.5% vs 5.7%
p-value: p=<0.05
Serum CRP in the early postoperative period can serve as a predictor for septic complications in patients undergoing colorectal cancer surgery.
Hypothesis-generating for early CRP monitoring to predict septic complications after colorectal cancer surgery; prospective validation needed before clinical adoption.
Prediction in colorectal surgery is very useful instrument in managing the health care system in hospitals. Searching for reliable risk factors of postoperative complications allows to identify patients of a high risk of complications group and to discharge earlier from hospital patients with a good prognosis. C-reactive protein is well known as a sensitive and dynamic marker of systemic inflammatory response syndrome. This study evaluated the feasibility of using C-reactive protein as predictor of septic postoperative complications. It was shown that analysis of serum CRP in early postoperative period allows to predict septic postoperative complications in colorectal cancer patients.
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Гатауллин et al. (2018) conducted a cohort in Colorectal cancer (n=278). Elevated C-reactive protein (CRP) levels vs. Normal or decreasing C-reactive protein (CRP) levels was evaluated on Mean C-reactive protein level on postoperative day 5 in patients with vs without septic complications (p=<0.05). Elevated C-reactive protein levels on the 5th postoperative day (12.5 mg/dL vs 5.7 mg/dL, p<0.05) significantly predicted the development of septic complications in patients undergoing colorectal cancer surgery.
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