Key result
C-reactive protein level ≥144.5 mg/l on the third postoperative day predicted anastomotic leakage after colorectal cancer surgery with 79.1% sensitivity and 60.3% specificity (AUC 0.715).
Why the study?
Does C-reactive protein level predict anastomotic leakage in patients after surgery for colorectal cancer?
Meta-Analysis
Does C-reactive protein level predict anastomotic leakage in patients after surgery for colorectal cancer?
Effect estimate: AUC 0.715 (95% CI 0.68-0.75)
Increased CRP levels, particularly ≥144.5 mg/l on the third postoperative day, can serve as an early predictor of anastomotic leakage after colorectal cancer surgery.
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Supports early anastomotic leak detection after colorectal cancer surgery; strengthens pooled diagnostic evidence for postoperative CRP monitoring.
Lyadov et al. (2020) conducted a meta-analysis in Colorectal cancer. C-reactive protein (CRP) was evaluated on Anastomotic leakage (AUC 0.715, 95% CI 0.68-0.75). C-reactive protein level ≥144.5 mg/l on the third postoperative day predicted anastomotic leakage after colorectal cancer surgery with 79.1% sensitivity and 60.3% specificity (AUC 0.715).
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