Key result
Prolonged elevation of C-reactive protein preceded anastomotic leakage, which occurred in 7.6% of patients and was associated with significantly higher in-hospital mortality (11.5% vs 2.8%).
Why the study?
Does prolonged elevation of serum CRP predict anastomotic leakage in patients undergoing colorectal surgery?
Population
342 patients undergoing colorectal resections with primary anastomosis
Comparison
Daily serum CRP measurement until postoperative… vs Patients who did not develop anastomotic leakage
Design
Cohort
Follow-up
Until postoperative day 7 or AL diagnosis
Authors
Loading...
May support serial CRP monitoring to flag anastomotic leak risk after colorectal surgery; hypothesis-generating and requires prospective validation.
Cohort (n=342)
No
Does prolonged elevation of serum CRP predict anastomotic leakage in patients undergoing colorectal surgery?
Absolute Event Rate: 11.5% vs 2.8%
Prolonged elevation and a missing decline in serum CRP levels precede the occurrence of anastomotic leakage after colorectal surgery.
Woeste et al. (2009) conducted a cohort in Colorectal surgery (n=342). Anastomotic leakage vs. No anastomotic leakage was evaluated on In-hospital mortality. Prolonged elevation of C-reactive protein preceded anastomotic leakage, which occurred in 7.6% of patients and was associated with significantly higher in-hospital mortality (11.5% vs 2.8%).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: