What is the clinical evidence from this study?

Study design: Observational. Population: Moderate to severe carbon monoxide poisoning (n=230). Intervention: Moderate to severe carbon monoxide poisoning. Primary outcome: Myocardial injury assessed by biomarkers or ECG.

What question did this study set out to answer?

To describe the cardiovascular manifestations and evaluate the extent of myocardial injury associated with moderate to severe carbon monoxide poisoning.

September 4, 2026Journal of the American College of Cardiology

Cardiovascular Manifestations of Moderate to Severe Carbon Monoxide Poisoning

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Key result

Moderate to severe carbon monoxide poisoning is linked to myocardial injury in ~37% of patients.

n=230

Population

230 consecutive patients treated for moderate to severe carbon monoxide poisoning in the hyperbaric oxygen…

Design

Cohort

Follow-up

in-hospital

Authors

DSDaniel SatranPark Nicollet Clinic CHChristopher R. HenryMarshall Space Flight Center CACheryl Adkinson

Discussion

Member takes

Implication

Cardiovascular sequelae of moderate to severe CO poisoning are frequent, suggesting the need for baseline ECG and serial cardiac biomarkers in these patients.

Key Points

To describe the cardiovascular manifestations and evaluate the extent of myocardial injury associated with moderate to severe carbon monoxide poisoning.
Reviewed records of 230 consecutive patients treated for moderate to severe carbon monoxide poisoning in a hyperbaric oxygen chamber at a regional medical center.
Assessed cardiac involvement via baseline electrocardiograms (ECGs) and measurement of serum cardiac biomarkers, specifically creatine kinase-MB fraction and troponin I.
Ischemic ECG changes occurred in 30% of patients, and only 16% presented with a normal ECG.
Cardiac biomarkers were elevated in 35% of patients, with overall myocardial injury identified by biomarkers or ECG in 37% of cases.
In-hospital mortality was 5% among the treated cohort.

Study Design

Type

Observational (n=230)

Multicenter

Structured PICO

Population

230 consecutive patients (mean age 47.2 years, 28% female) treated for moderate to severe carbon monoxide poisoning in a hyperbaric oxygen chamber.

Outcome

Cardiovascular manifestations including ischemic ECG changes, cardiac biomarker elevation, and in-hospital mortalitysurrogate

Cardiovascular sequelae of moderate to severe CO poisoning are frequent, suggesting the need for baseline ECG and serial cardiac biomarkers in these patients.

Cite This Study

Satran et al. (2005) conducted an observational in Moderate to severe carbon monoxide poisoning (n=230). Moderate to severe carbon monoxide poisoning was evaluated on Myocardial injury assessed by biomarkers or ECG. Moderate to severe carbon monoxide poisoning frequently caused cardiovascular sequelae, with myocardial injury (by biomarkers or ECG) present in 37% of patients and 5% in-hospital mortality.

synapsesocial.com/papers/6a9a3897eebad2e0111bf458 https://doi.org/10.1016/j.jacc.2005.01.044

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Implication

Cardiovascular sequelae of moderate to severe CO poisoning are frequent, suggesting the need for baseline ECG and serial cardiac biomarkers in these patients.

Cardiovascular Manifestations of Moderate to Severe Carbon Monoxide Poisoning

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Cardiovascular Manifestations of Moderate to Severe Carbon Monoxide Poisoning

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

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Also Consider