A new method for quantification of aortic stiffness in vivo using magnetic resonance elastography (MRE): a translational study from sequence design to implementation in patients
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Key result
A novel transducer-free magnetic resonance elastography technique successfully measured aortic stiffness in vivo, demonstrating strong correlation with the reference standard applanation tonometry (R2=0.78, p<0.0001).
Why the study?
Does transducer-free magnetic resonance elastography (MRE) accurately measure aortic stiffness compared to applanation tonometry in volunteers and hypertensive patients?
Population
8 volunteers and 15 hypertensive patients, as well as simple geometry and aortic phantoms.
Comparison
Transducer-free magnetic resonance elastography… vs Applanation tonometry, and other MR methods.
Design
Other
Authors
Discussion
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Implication
Supports feasibility of transducer-free MRE for aortic stiffness; leaves open larger validation and outcome studies before clinical use.
Study Design
Type
Observational (n=23)
Multicenter
No
Structured PICO
Does transducer-free magnetic resonance elastography (MRE) accurately measure aortic stiffness compared to applanation tonometry in volunteers and hypertensive patients?
P
Population
23 participants, comprising 8 healthy volunteers and 15 hypertensive patients, evaluated for aortic stiffness using a novel magnetic resonance elastography technique.
I
Intervention
Transducer-free magnetic resonance elastography (MRE) sequence to measure aortic stiffness in vivo using aortic valve closure to generate shear waves.
C
Comparator
Applanation tonometry (current non-invasive reference standard), and other MR methods (QA Loop, transit-time [TT]).
O
Outcome
Correlation and agreement of aortic stiffness measurements with the reference standard applanation tonometry.surrogate
Main Result
Effect estimate: R2=0.78 (95% CI 0.69-0.96)
p-value: p=<0.0001
A novel transducer-free MRE technique using aortic valve closure to generate shear waves can accurately measure local aortic stiffness in vivo, showing strong correlation with applanation tonometry.
Cite This Study
Clough et al. (2015) conducted an observational in Aortic stiffness (n=23). Magnetic resonance elastography (MRE) vs. Applanation tonometry was evaluated on Correlation and agreement of MRE with applanation tonometry for measurement of aortic stiffness (R2=0.78, 95% CI 0.69-0.96, p=<0.0001). A novel transducer-free magnetic resonance elastography technique successfully measured aortic stiffness in vivo, demonstrating strong correlation with the reference standard applanation tonometry (R2=0.78, p<0.0001).
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