Key result
Myocardial external efficiency was lower in genotype positive/phenotype negative patients than controls (28% vs 42%) and further decreased in HOCM (22%), with no improvement after myectomy surgery.
Why the study?
Does myectomy surgery improve myocardial efficiency in patients with hypertrophic obstructive cardiomyopathy?
Observational
Does myectomy surgery improve myocardial efficiency in patients with hypertrophic obstructive cardiomyopathy?
Absolute Event Rate: 22% vs 42%
Myocardial efficiency is reduced early in hypertrophic cardiomyopathy and is not improved by myectomy surgery in advanced stages, suggesting metabolic therapies should be initiated before cardiac remodeling.
No takes yet. Share an insight, caveat, or question.
Myocardial efficiency fails to improve after myectomy in HOCM unlike aortic stenosis; leaves open stage-specific energetic targets pending prospective trials.
Güçlü et al. (2017) conducted an observational in Hypertrophic cardiomyopathy. Hypertrophic cardiomyopathy disease stage and myectomy surgery vs. Healthy controls and aortic valve stenosis patients was evaluated on Myocardial external efficiency (MEE). Myocardial external efficiency was lower in genotype positive/phenotype negative patients than controls (28% vs 42%) and further decreased in HOCM (22%), with no improvement after myectomy surgery.
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