Key result
Glucose levels during sleep showed a moderate negative correlation with heart rate variability (r = -0.453), indicating that glucose fluctuations can reflect autonomic nervous system activity.
Why the study?
This study investigated whether glucose fluctuations could serve as a measure of stress by examining the relationship between heart rate variability and glucose levels during sleep in healthy subjects.
Do glucose fluctuations correlate with heart rate variability during sleep in healthy subjects?
Cross-Sectional (n=5)
No
Do glucose fluctuations correlate with heart rate variability during sleep in healthy subjects?
Glucose fluctuations during sleep show a moderate negative correlation with heart rate variability, suggesting they could serve as a surrogate indicator of autonomic nervous system activity and stress.
Higher glucose linked to lower sleep HRV in healthy subjects; hypothesis-generating for autonomic stress but should not change practice.
Objective The body’s glucose concentration is influenced by carbohydrate intake, insulin-induced carbohydrate reduction, and hepatic glycogen breakdown induced by stress hormones. This study investigated the potential of employing glucose fluctuations as a measure of stress by examining the relationship between heart rate variability (HRV) data and glucose levels during sleep in healthy subjects. Methods In this cross-sectional study, a chest-worn electrocardiogram (ECG) and continuous glucose monitoring device (CGM) were respectively used to monitor the heart rate intervals and glucose fluctuations of five subjects (two males, three females) during sleep. A time-series correlation analysis was performed on the HRV data extracted from heart rate intervals and the corresponding glucose fluctuation data. Results The time-series analysis of ECG and CGM data collected from subjects during sleep (n = 25 nights) revealed a moderate negative correlation between glucose levels and HRV, with a cross-correlation coefficient of r = –0.453. Conclusion Similar to HRV, changes in stress levels can be detected by observing glucose fluctuations, particularly during sleep when the impact of food intake can be eliminated. Our findings highlight a significant correlation between glucose levels and HRV, indicating that glucose fluctuations can be used as an indicator of autonomic nervous system activity.
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Kajisa et al. (2023) conducted a cross-sectional in Healthy (n=5). Glucose fluctuations during sleep was evaluated on Cross-correlation between glucose levels and heart rate variability (HRV) during sleep (r = -0.453). Glucose levels during sleep showed a moderate negative correlation with heart rate variability (r = -0.453), indicating that glucose fluctuations can reflect autonomic nervous system activity.
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