Key result
Tax1-immortalized T-cells exhibited elevated levels of conformationally wild-type p53 and impaired p53 transactivating function compared with normal T-cells.
Population
T-cells immortalized by the Tax1 protein of HTLV-I
Comparison
Tax1 protein of HTLV-I vs Normal T-cells
Design
Preclinical
Authors
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Highlights Tax1-p53 dysfunction in HTLV-I T-cell transformation; leaves open therapeutic targeting in ATL.
The Tax1 protein of HTLV-I causes aberrant expression and impaired transactivating function of p53 in immortalized T-cells.
Akagi et al. (1997) studied HTLV-I immortalized T-cells. HTLV-I Tax1 immortalization vs. Normal T-cells was evaluated on p53 expression and transactivating function. Tax1-immortalized T-cells exhibited elevated levels of conformationally wild-type p53 and impaired p53 transactivating function compared with normal T-cells.
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