Key result
Primary percutaneous coronary intervention resulted in significantly greater mean ST-segment resolution at 60 minutes compared to fibrinolysis with streptokinase (63.54% vs 33.97%, p<0.001).
Why the study?
Does primary percutaneous coronary intervention improve ST-segment resolution and in-hospital outcomes compared to fibrinolysis with streptokinase in patients with acute STEMI?
Does primary percutaneous coronary intervention improve ST-segment resolution and in-hospital outcomes compared to fibrinolysis with streptokinase in patients with acute STEMI?
Absolute Event Rate: 63.54% vs 33.97%
p-value: p=<0.001
Primary PCI provides earlier and more complete ST-segment resolution and better in-hospital clinical outcomes compared to streptokinase fibrinolysis in acute STEMI.
PPCI may achieve faster, more complete ST resolution and fewer in-hospital complications than fibrinolysis in STEMI; leaves open whether findings hold in randomized trials.
Background: Coronary artery disease (CAD) is the most common cause of mortality & morbidity in all over the world. Reperfusion therapy is the cornerstone for treating acute ST-segment elevation myocardial infarction. Effective reperfusion in STEMI can be achieved by either fibrinolysis or primary percutaneous coronary intervention (PPCI). PPCI generally produces better outcomes than fibrinolysis but is not widely available. ST-segment abnormalities play a fundamental role in assessment and decision making for patients with STEMI. Methods: This quasi-experimental study was conducted in the Department of Cardiology, National Heart Foundation Hospital and Research Institute. Group I underwent primary PCI and group II received fibrinolytic therapy as reperfusion therapy for acute STEMI.Results: The mean ST-segment resolutions were significantly more in group I than group II at 60 minutes (63.54±20.98 vs 33.97±15.88%, p<0.001) and at 90 minutes (73.15±18.76 vs 60.06±23.33%, p<0.015). However the difference is not significant at 180 minutes after procedure (74.48±18.09 vs 65.33±21.20%, p=0.064). In our study we observed that significantly higher number of patients of group II developed acute LVF (33.3% vs 6.1%, p=0.005) and cardiogenic shock (18.2% vs 3.0%, p=0.046) than group I and Rescue PCI was needed in 5 (15.2%% vs 0%, p=0.020) patients of group II than group I. Conclusion: ST-segment resolution occurs earlier and more completely after Primary percutaneous coronary intervention than fibrinolysis (with Streptokinase) with better in hospital outcome in patients with acute STEMI.Bangladesh Journal of Medical Science Vol.15(2) 2016 p.252-256
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Rahman et al. (2016) studied Acute ST-segment elevation myocardial infarction (STEMI) (n=66). Primary percutaneous coronary intervention (PPCI) vs. Fibrinolysis (with streptokinase) was evaluated on Mean ST-segment resolution at 60 minutes after procedure (p=<0.001). Primary percutaneous coronary intervention resulted in significantly greater mean ST-segment resolution at 60 minutes compared to fibrinolysis with streptokinase (63.54% vs 33.97%, p<0.001).
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