Key result
Higher serum log(YKL-40) levels were independently associated with the presence of left atrial fibrosis in patients with lone paroxysmal atrial fibrillation (OR 1.626, P=0.022).
Why the study?
Is serum YKL-40 associated with the presence and extent of left atrial fibrosis in patients with lone paroxysmal atrial fibrillation?
Cross-Sectional (n=50)
Is serum YKL-40 associated with the presence and extent of left atrial fibrosis in patients with lone paroxysmal atrial fibrillation?
Odds Ratio: 1.626
p-value: p=0.022
Serum YKL-40 is independently associated with the presence and extent of left atrial fibrosis in patients with lone paroxysmal atrial fibrillation, suggesting its potential as a biomarker for atrial structural remodeling.
May aid noninvasive fibrosis detection in lone paroxysmal AF; hypothesis-generating and requires prospective validation.
BACKGROUND: Assessment of the left atrial (LA) fibrosis by using delayed-enhanced magnetic resonance imaging (DE-MRI) in atrial fibrillation (AF) patients is a pioneering noninvasive method. Serum YKL-40 is a novel marker for inflammation and known to play a role in ongoing tissue fibrosis. However, its role in LA fibrosis is unclear. We aimed to investigate the association of serum YKL-40 with the presence and extent of LA fibrosis. METHODS: A total of 50 patients with lone paroxysmal AF (62% male; age: 47.2 ± 7.0 years) underwent cardiac DE-MRI according to study protocol. Cardiac DE-MRI at 1.5 Tesla scanner was used to quantify LA fibrosis. Serum YKL-40 levels and clinical and echocardiographic data were recorded in all participants. RESULTS: DE-MRI revealed any degree of LA fibrosis in 31 (62%) patients. Median serum YKL-40 was significantly higher (P = 0.008) and left venticular ejection fraction was lower (P = 0.047) in patients with LA fibrosis as compared to patients without LA fibrosis. Extent of LA fibrosis was significantly correlated with age, duration of AF history, serum C-reactive protein, and serum YKL-40 levels. Only log (YKL-40) level was found as independent predictor for the presence of LA fibrosis (odds ratio: 1.626, P = 0.022). Multivariate linear regression analysis pointed out that duration of AF history (β = 0.330, P = 0.003) and serum log (YKL-40) levels (β = 0.546, P < 0.001) were significantly and independently associated with the extent of LA fibrosis. CONCLUSION: Higher levels of serum YKL-40 are associated with the presence and more extensive LA fibrosis in patients with lone AF. As a marker of inflammation, serum YKL-40 may also be used as an indicator for the degree of LA fibrosis.
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Canpolat et al. (2015) conducted a cross-sectional in Lone paroxysmal atrial fibrillation (n=50). Serum YKL-40 levels was evaluated on Presence of left atrial fibrosis (OR 1.626, p=0.022). Higher serum log(YKL-40) levels were independently associated with the presence of left atrial fibrosis in patients with lone paroxysmal atrial fibrillation (OR 1.626, P=0.022).
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