Key result
Muscle biopsies from patients with autosomal dominant hyaline body myopathy showed hyaline bodies in type 1 fibers associated with myolysis or defective incorporation of heavy chain slow myosin.
Observational (n=4)
Hyaline body formation in this myopathy is associated with myolysis or defective incorporation of heavy chain slow myosin, with involvement of neurogenic factors.
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May refine biopsy interpretation in hyaline body myopathy; leaves open mechanistic and neurogenic roles pending larger studies.
Bohlega et al. (2003) conducted an observational in Autosomal dominant hyaline body myopathy (n=4). Autosomal dominant hyaline body myopathy was evaluated on Clinical, morphologic, and immunohistochemical characteristics of muscle biopsies. Muscle biopsies from patients with autosomal dominant hyaline body myopathy showed hyaline bodies in type 1 fibers associated with myolysis or defective incorporation of heavy chain slow myosin.
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