Photinides A−F, Cytotoxic Benzofuranone-Derived γ-Lactones from the Plant Endophytic Fungus Pestalotiopsis photiniae

Photinides A-F (1-6), six new unique benzofuranone-derived gamma-lactones, have been isolated from the crude extract of the plant endophytic fungus Pestalotiopsis photiniae. The structures of these compounds were elucidated primarily by NMR spectroscopy, and their absolute configurations were assigned by application of the CD excitation chirality method. Compounds 1-6 displayed modest cytotoxic effects against the human tumor cell line MDA-MB-231.