Key result
Patients with creatinine clearance 21 to 40 mL/min were less likely to be prescribed ACE inhibitors than those with >60 mL/min (27% vs 38%; P=0.003 for trend).
Population
3,089 adult hypertensive subjects treated at Brigham and Women's Hospital from 1990 through 1998, with at…
Design
Cohort
Follow-up
at least 2 years
Authors
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ACE inhibitor underuse in moderate CKD may worsen BP control; hypothesis-generating for barriers and targeted interventions in this population.
Observational (n=3,089)
No
Absolute Event Rate: 27% vs 38%
p-value: p=.003 for trend
In hypertensive patients with chronic renal insufficiency, blood pressure control is suboptimal and ACE inhibitor prescription rates paradoxically decrease with worsening renal function.
Chi‐yuan Hsu (2001) conducted an observational in Hypertension with chronic renal insufficiency (n=3,089). Severe chronic renal insufficiency (CrCl 21-40 mL/min) vs. CrCl >60 mL/min was evaluated on ACE inhibitor prescription (p=.003 for trend). Patients with creatinine clearance 21 to 40 mL/min were less likely to be prescribed ACE inhibitors than those with >60 mL/min (27% vs 38%; P=0.003 for trend).
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