January 1, 1998BioFactors
Neuroprotective versus neurodestructive effects of NO‐related species
Key result
Nitric oxide exhibits both neurodestructive effects via peroxynitrite formation and neuroprotective effects through S-nitrosylation of NMDA receptor cysteine sulfhydryls.
Population
Central nervous system models and recombinant NMDA receptor subunits
Design
Review
Authors
Discussion
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Member takes
Implication
Dual NO effects in CNS advise against indiscriminate modulation; leaves open redox-targeted therapies for validation in trials.
Structured PICO
P
Population
Central nervous system models and recombinant NMDA receptor subunits
E
Exposure
Nitric oxide (NO) and redox-related species
O
Outcome
Neuroprotective versus neurodestructive effects
Nitric oxide exerts dual neuroprotective and neurodestructive effects in the central nervous system depending on its redox state and interactions.
Cite This Study
Lipton et al. (1998) conducted a review in Central nervous system injury and neuroprotection. Nitric oxide (NO) and redox-related species was evaluated. Nitric oxide exhibits both neurodestructive effects via peroxynitrite formation and neuroprotective effects through S-nitrosylation of NMDA receptor cysteine sulfhydryls.