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Multiple studies suggest a common coexistence of type 2 diabetes mellitus (T2DM) and cancer, especially colorectal cancer (CC). One of the most important mechanism that may have an impact on the increased incidence of cancer in diabetes is deregulation in the immune system. Interferon gamma (IFN), a cytokine critical for anti-tumor immunity, enhances cytotoxic activity of Tc lymphocytes, natural killer (NK) cells, activates macrophages, affects the apoptosis and induces the production of other cytokines such as IL-2, IL-6. The aim of this study was to evaluate the concentration of IFN in patients with T2DM with accompanying colorectal cancer compared to patients with T2DM or colorectal cancer separately.
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Bosek et al. (2015) studied this question.
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