Key result
Shen-Yuan-Dan Capsule significantly decreased atherosclerotic plaque area, total cholesterol, triglycerides, and LDL-C in ApoE -/- mice fed a high-fat diet compared to control.
Why the study?
Does Shen-Yuan-Dan Capsule reduce atherosclerotic plaque and lipid levels in Apolipoprotein E knockout mice fed a high-fat diet?
Does Shen-Yuan-Dan Capsule reduce atherosclerotic plaque and lipid levels in Apolipoprotein E knockout mice fed a high-fat diet?
Shen-Yuan-Dan Capsule reduces atherosclerosis and lipid levels in a mouse model by inhibiting inflammation via the IRS-1/PI3K/Akt/NF-κB signaling pathway.
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Zhou et al. (2017) studied Atherosclerosis (n=40). Shen-Yuan-Dan Capsule (SYDC) vs. Distilled water (control) and Lipitor was evaluated on Atherosclerotic plaque area and lipid profiles (TC, TG, LDL-C, AI) (p=<0.05). Shen-Yuan-Dan Capsule significantly decreased atherosclerotic plaque area, total cholesterol, triglycerides, and LDL-C in ApoE -/- mice fed a high-fat diet compared to control.
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