Key result
Elevated Lp(a) was independently associated with an increased risk of calcific aortic valve disease (OR 5.798), while Fetuin-A was identified as a protective factor (OR 0.209).
Why the study?
Calcific aortic valve disease imposes a substantial, increasing burden in the ageing population with an occult onset, prompting assessment of clinical characteristics associated with its occurrence.
Are Fetuin-A, Lp(a), and matrix gla protein associated with the occurrence of calcific aortic valve disease?
Case-Control (n=362)
No
Are Fetuin-A, Lp(a), and matrix gla protein associated with the occurrence of calcific aortic valve disease?
Odds Ratio: 5.798 (95% CI 3.001–8.678)
p-value: p=<0.001
Fetuin-A, MGP, and Lp(a) are independently associated with the occurrence of calcific aortic valve disease and may serve as potential diagnostic predictors.
BACKGROUND: Calcific aortic valve disease (CAVD) has a substantial and increasing burden in the ageing population with occult onset.Present study aimed to assess association of clinical characteristics of these patients and occurrence of CAVD. METHODS: Patients diagnosed with CAVD and those receiving healthy medical examination in our hospital from January 2019 to February 2021 were enrolled in this retrospective study. Clinical characteristics, ultrasonic indicators, serological indicators and histology of CAVD were collected and compared among different groups. Logistic regression and Pearson correlation analysis was used to explore relationship between these indexes and occurrence of CAVD. RESULTS: DBP, SBP, LVESD, LVEDD, IVS, PW, AV Vmax, TC, TG, LDL-C, Fetuin-A, Lp(a) in severe group were higher than mild, moderate and control groups (P<0.05), while those indexes of patients in moderate group were higher than that in mild and controlled groups (P<0.05). Besides, theses indexes of patients in mild group were also higher than that of controlled one (P<0.05). However, LVEF, HDL-C and MGP of patients in severe group was the lowest (P<0.05), while those in moderate group were lower than mild and controlled groups. Moreover, these indexes in mild group were also lower than control group (P<0.05). In Logistic regression analysis, MGP, Fetuin-A and Lp(a) were all independently associated with occurrence of CAVD (P<0.05). In Pearson correlation analysis, Fetuin-A and Lp(a) were positively correlated with progression of the disease, while MGP and macrophage density were negatively correlated with it. CONCLUSIONS: Fetuin-A, MPG and Lp(a) were independently associated with the occurrence of CAVD, and they might be potential predictors for diagnosis of this disease.
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Liu et al. (2022) conducted a case-control in Calcific aortic valve disease (n=362). Fetuin-A, Lp(a), and Matrix Gla protein vs. Healthy controls was evaluated on Occurrence of calcific aortic valve disease (OR 5.798, 95% CI 3.001-8.678, p=<0.001). Elevated Lp(a) was independently associated with an increased risk of calcific aortic valve disease (OR 5.798), while Fetuin-A was identified as a protective factor (OR 0.209).
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