Key result
Elevated homocysteine levels appear to hold predictive value for future paroxysmal atrial fibrillation events, potentially mediated through mechanisms such as oxidative stress and cardiac remodeling.
Why the study?
High homocysteine levels are linked with adverse cardiovascular outcomes, but its value in predicting future paroxysms of atrial fibrillation and underlying mechanisms needed clarification.
Do elevated homocysteine levels predict future paroxysms of atrial fibrillation?
Do elevated homocysteine levels predict future paroxysms of atrial fibrillation?
Answers are grounded in this paper and cite their sources.
Homocysteine levels may serve as a useful biomarker for predicting future events in patients with paroxysmal atrial fibrillation.
High levels of homocysteine (Hcy) have been linked with adverse cardiovascular outcomes, such as arrhythmias and stroke. In the context of paroxysmal atrial fibrillation (PAF), hyperhomocysteinemia has been demonstrated to be an independent predictor of future events. The aim of this report was to address the potential value of Hcy levels in predicting future paroxysms of atrial fibrillation (AF), as well as to identify the potential mechanisms of action. We searched PubMed and the Cochrane Database on 16 January 2022. Keywords used were homocysteine or hyperhomocysteinemia paired with a total of 67 different keywords or phrases that have been implicated with the pathogenesis of AF. We included primary reports of clinical and non-clinical data in the English language, as well as systematic reviews with or without meta-analyses. We placed no time constraints on our search strategy, which yielded 3748 results. Following title review, 3293 reports were excluded and 455 reports were used for title and abstract review, after which 109 reports were finally used for full-text review. Our review indicates that Hcy levels seem to hold a predictive value in PAF. Herein, potential mechanisms of action are presented and special considerations are made for clinically relevant diagnostic procedures that could complement plasma levels in the prediction of future PAF events. Finally, gaps of evidence are identified and considerations for future clinical trial design are presented.
No takes yet. Share an insight, caveat, or question.
Charalampidis et al. (2022) conducted a review in Paroxysmal Atrial Fibrillation (n=74). Elevated homocysteine levels vs. Normal homocysteine levels was evaluated on Prediction of future paroxysms of atrial fibrillation. Elevated homocysteine levels appear to hold predictive value for future paroxysmal atrial fibrillation events, potentially mediated through mechanisms such as oxidative stress and cardiac remodeling.
Synapse has enriched 10 related papers. Consider them for comparative context: