Why the study?
Are body mass index and waist circumference associated with in-hospital and peri-hospital mortality in patients with acute coronary syndrome?
Cohort
Yes
Are body mass index and waist circumference associated with in-hospital and peri-hospital mortality in patients with acute coronary syndrome?
Obesity measures (BMI and waist circumference) are not independently associated with in-hospital or peri-hospital mortality in patients with ACS after adjusting for confounders, challenging the concept of an obesity paradox in this population.
Answers are grounded in this paper and cite their sources.
Obesity metrics should not inform ACS mortality risk assessment; leaves open whether obesity paradox applies to in-hospital outcomes.
We investigated the association between in-hospital and peri-hospital mortality and body mass index (BMI)/waist circumference (WC) in a prospective acute coronary syndrome (ACS) registry in the Arabian Gulf. No significant associations with in-hospital mortality were found. Normal BMI had highest peri-hospital mortality, notably those with high WC. In logistic regression of mortality on obesity measures and potential confounders, the effects of obesity measures were no longer significant. In-hospital death increased by 5% with age and decreased by 42% in males. Mortality increased 3.7-fold with ST-elevation myocardial infarction (STEMI) and 3.0-fold with heart failure (HF) but decreased by 33% with dyslipidemia. Peri-hospital death increased by 4% with age and decreased by 30% in males. Mortality increased 2.8-fold with STEMI and 2.4-fold with HF. In- and peri-hospital mortality in ACS is significantly associated with age, gender, STEMI, HF, and dyslipidemia but not obesity measures.
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Shehab et al. (2013) conducted a cohort in Acute Coronary Syndrome. Body mass index and waist circumference was evaluated on In-hospital and peri-hospital mortality.
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